Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-(phenylsulfonyl)-
There total 3 articles about 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-(phenylsulfonyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-fluoro-1H-pyrrolo[2,3‐b]pyridine;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.5h;
benzenesulfonyl chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 12 h / 130 °C
2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 1 h / 0 - 20 °C
With
potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / toluene / 0.5 h / 20 °C / Inert atmosphere
1.2: 11.5 h / 60 °C / Inert atmosphere
2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 12 h / 130 °C
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
3.2: 1 h / 0 - 20 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium tert-butylate; sodium hydride; triethylamine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; toluene; mineral oil;