((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Chemical Name:((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester
CAS No.:199005-63-5
Molecular Formula:C₄₇H₅₀N₄O₆
Molecular Weight:766.937
Hs Code.:

Synonyms:((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Chemical Property of ((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Technology Process of ((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

There total 9 articles about ((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 199006-32-1
((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

: 199005-63-5
((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; for 3h; Ambient temperature;
DOI:10.1021/jm980071x

Reference yield:

: 76-84-6
triphenylmethyl alcohol

: 199005-63-5
((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / glac. acetic acid, acetic anhydride, sulfuric acid / 1 h / 55 °C

2: 84 percent / acetyl chloride / methanol / 1 h / Ambient temperature

3: 72 percent / LiCl, NaBH₄ / tetrahydrofuran; ethanol / Ambient temperature

4: 100 percent / H₂ / 10percent Pd/C / methanol / 2 h

5: dimethylformamide / Ambient temperature

6: 93 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 3 h / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; hydrogen; acetic anhydride; acetic acid; acetyl chloride; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm980071x

Reference yield:

: 2650-64-8
Cbz-L-Gln

: 199005-63-5
((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / glac. acetic acid, acetic anhydride, sulfuric acid / 1 h / 55 °C

2: 84 percent / acetyl chloride / methanol / 1 h / Ambient temperature

3: 72 percent / LiCl, NaBH₄ / tetrahydrofuran; ethanol / Ambient temperature

4: 100 percent / H₂ / 10percent Pd/C / methanol / 2 h

5: dimethylformamide / Ambient temperature

6: 93 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 3 h / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; hydrogen; acetic anhydride; acetic acid; acetyl chloride; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm980071x