Z-LEU-PHE-OH

Base Information

• Chemical Name: Z-LEU-PHE-OH
• CAS No.: 6401-63-4
• Molecular Formula: C23H28 N2 O5
• Molecular Weight: 412.486
• Mol file: 6401-63-4.mol

Synonyms:Alanine,N-(N-carboxy-L-leucyl)-3-phenyl-, N-benzyl ester (7CI); Alanine,N-(N-carboxy-L-leucyl)-3-phenyl-, N-benzyl ester, L- (8CI); L-Phenylalanine,N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-;Carbobenzoxy-L-leucyl-L-phenylalanine; Z-Leu-Phe

Chemical Property of Z-LEU-PHE-OH

Chemical Property:

• Melting Point: 119-121 °C
• Boiling Point: 654.9±55.0 °C(Predicted)
• PKA: 3.54±0.10(Predicted)
• PSA: 104.73000
• Density: 1.193±0.06 g/cm3(Predicted)
• LogP: 3.92140
• Storage Temp.: -15°C

Purity/Quality:

HPLC>98% ^*data from raw suppliers

Z-Leu-Phe-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-LEU-PHE-OH

There total 17 articles about Z-LEU-PHE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester (10473-38-8,16679-86-0,120342-23-6,4818-00-2) → N-benzyloxycarbonyl-L-leucyl-L-phenylalanine (6401-63-4)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1021/jm1009567

Reference yield: 89.0%

CBZ-Leu-Phe-OC(CH3)3 (6401-57-6) → N-benzyloxycarbonyl-L-leucyl-L-phenylalanine (6401-63-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 12h;

DOI:10.1016/S0040-4020(01)91366-3

Reference yield: 76.0%

Z-Leu-OH (2018-66-8) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-benzyloxycarbonyl-L-leucyl-L-phenylalanine (6401-63-4)

Guidance literature:

Z-Leu-OH; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Green chemistry;

L-phenylalanine; With water; In tetrahydrofuran; at 0 ℃; for 0.5h; Green chemistry;

DOI:10.1016/j.tetasy.2016.11.009

upstream raw materials:

ethyl N-benzyloxycarbonyl-L-leucyl-L-phenylalaninate

N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester

Cbz-Leu-Phe-NH₂

CBZ-Leu-Phe-OC(CH₃)3

Downstream raw materials:

Leu-Phe-OH

N-benzyloxycarbonyl-leucyl=>phenylalanyl=>glycine ethyl ester

Z-Leu-Phe-Phe-OMe

Z-S-Leu-S-Phe-S-Val-OtBu