[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Base Information

Chemical Name:[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone
CAS No.:1380284-61-6
Molecular Formula:C₂₉H₃₀ClFN₄O
Molecular Weight:505.035
Hs Code.:

Synonyms:[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Suppliers and Price of [3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

There total 6 articles about [3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 2,2-dimethylpropanimidamide hydrochloride

: 1380284-65-0
3-Acetyl-6-chloro-5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-indole-1-carboxylic acid benzyl ester

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1380284-61-6
[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Guidance literature:: 3-Acetyl-6-chloro-5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-indole-1-carboxylic acid benzyl ester; N,N-dimethylformamide di-tert-butyl acetal; In N,N-dimethyl-formamide; at 75 ℃; for 5h;

2,2-dimethylpropanimidamide hydrochloride; In N,N-dimethyl-formamide; at 85 ℃; for 18h;

Reference yield:

: 4-acetylamino-5-iodo-2-chloro-benzoic acid methyl ester

: 1380284-61-6
[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 16 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / Reflux; Inert atmosphere

3.1: diethylaluminium chloride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

3.3: Tris buffer / pH 7.5

4.1: sodium hydroxide / 1,4-dioxane / 20 - 60 °C

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

5.2: 3 h / 20 °C / Cooling with ice; Inert atmosphere

6.1: dmap; triethylamine / tetrahydrofuran / 1.5 h / 20 °C

7.1: N,N-dimethyl-formamide / 5 h / 75 °C

7.2: 18 h / 85 °C

With dmap; copper(l) iodide; tetrabutyl ammonium fluoride; diethylaluminium chloride; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 162100-83-6
6-chloro-1H-indole-5-carboxylic acid methyl ester

: 1380284-61-6
[3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylaluminium chloride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C

1.3: Tris buffer / pH 7.5

2.1: sodium hydroxide / 1,4-dioxane / 20 - 60 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: dmap; triethylamine / tetrahydrofuran / 1.5 h / 20 °C

5.1: N,N-dimethyl-formamide / 5 h / 75 °C

5.2: 18 h / 85 °C

With dmap; diethylaluminium chloride; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;