4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

Base Information

Chemical Name:4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide
CAS No.:1287760-83-1
Molecular Formula:C₂₃H₁₈F₃N₅O₃S
Molecular Weight:501.489
Hs Code.:

Synonyms:4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

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Technology Process of 4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

There total 7 articles about 4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 476322-49-3
4-(3-amino-5-phenyl-pyrazol-1-yl)-benzenesulfonamide

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1287760-83-1
4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: 1287760-82-0
[5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]-carbamic acid ethyl ester

: 1287760-83-1
4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / ethanol / 5 h / Reflux; Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With water; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2001376

Reference yield:

: potassium salt of ethyl 2-hydroxy-4-oxo-4-phenyl-2-butenoate

: 1287760-83-1
4-{5-phenyl-3-[3-(3-trifluoromethylphenyl)-ureido]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: diphenylphosphoranyl azide; triethylamine / 1,4-dioxane / 12 h / Inert atmosphere; Reflux

4.1: water; sodium hydroxide / ethanol / 5 h / Reflux; Inert atmosphere

5.1: triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With diphenylphosphoranyl azide; water; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 3.1: Curtius rearrangement;
DOI:10.1021/jm2001376