1-benzoylcyclooctanol

Base Information

• Chemical Name: 1-benzoylcyclooctanol
• CAS No.: 172230-04-5
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 232.323
• Mol file: 172230-04-5.mol

Synonyms:1-benzoylcyclooctanol

Chemical Property of 1-benzoylcyclooctanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzoylcyclooctanol

There total 2 articles about 1-benzoylcyclooctanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

1-((trimethylsilyl)oxy)cyclooctanecarbonitrile (50361-50-7) + phenylmagnesium bromide (100-58-3) → 1-benzoylcyclooctanol (172230-04-5)

Guidance literature:

In diethyl ether; for 3h; Ambient temperature;

DOI:10.1248/cpb.43.1294

Reference yield:

cycloactanone (502-49-8) → 1-benzoylcyclooctanol (172230-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.7 percent / n-BuLi / hexane; tetrahydrofuran / 2 h / Ambient temperature

2: 83.7 percent / diethyl ether / 3 h / Ambient temperature

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1248/cpb.43.1294

Reference yield: 77.7%

1-benzoylcyclooctanol (172230-04-5) → cyclooctyl(phenyl)methanone (6004-59-7) + benzylcyclooctane (4410-76-8)

Guidance literature:

With acetic acid; zinc; at 60 ℃; for 12h;

DOI:10.1248/cpb.43.1294

upstream raw materials:

1-((trimethylsilyl)oxy)cyclooctanecarbonitrile

phenylmagnesium bromide

cycloactanone

Downstream raw materials:

(E)-cyclooct-1-en-1-yl(phenyl)methanone

cyclooctyl(phenyl)methanone

benzylcyclooctane