[N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine

Base Information

• Chemical Name: [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine
• CAS No.: 1158443-10-7
• Molecular Formula: C₁₉H₂₅N₅O₄
• Molecular Weight: 387.439
• Mol file: 1158443-10-7.mol

Synonyms:[N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine

Chemical Property of [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine

There total 1 articles about [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

N‐[(4‐methoxyphenyl)methyl]‐N‐methylcarbamoyl chloride (55245-86-8) + tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate (152120-61-1) → [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine (1158443-10-7)

Guidance literature:

tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

N‐[(4‐methoxyphenyl)methyl]‐N‐methylcarbamoyl chloride; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1016/j.bmc.2009.02.047

Reference yield: 99.0%

[N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine (1158443-10-7) + C91H158N6O12 (1324007-48-8) → C107H179N9O16 (1324007-50-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.tet.2011.05.073

Reference yield: 83.0%

trifluoroethylamine (753-90-2) + [N-(tert-butoxycarbonyl)-N'-{N-(p-methoxybenzyl)-N-methylcarbamoyl}]-1H-pyrazole-1-carboxamidine (1158443-10-7) → N-tert-butoxycarbonyl-N'-(2,2,2-trifluoroethyl)-N''-(N-methyl-N-p-methoxybenzylcarbamoyl)guanidine (1158443-39-0)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 25h;

DOI:10.1016/j.bmc.2009.02.047

upstream raw materials:

N‐[(4‐methoxyphenyl)methyl]‐N‐methylcarbamoyl chloride

tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate

Downstream raw materials:

N-tert-butoxycarbonyl-N'-(2,2,2-trifluoroethyl)-N''-(N-methyl-N-p-methoxybenzylcarbamoyl)guanidine

C₁₀₇H₁₇₉N₉O₁₆