[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Base Information

Chemical Name:[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid
CAS No.:783362-42-5
Molecular Formula:C₂₁H₃₁N₃O₇
Molecular Weight:437.493
Hs Code.:

[4-(2-acetylamino-6-<i>tert</i>-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Synonyms:[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

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Chemical Property of [4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Chemical Property:

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Technology Process of [4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

There total 9 articles about [4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 783362-31-2
{4-[acetyl-Lys(Boc)amino]-phenyl}-hydroxy-acetic acid methyl ester

: 783362-42-5
[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 2h;
DOI:10.1039/b404471a

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 783362-42-5
[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / SOCl₂ / 24 h / 20 °C

2: 85 percent / NBS / CCl₄ / 5 h / Irradiation

3: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

4: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

5: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

6: 84 percent / HATU; collidine / dimethylformamide / 12 h

7: piperidine; TFA / dimethylformamide / 0.5 h

8: DIEA / CH₂Cl₂ / 1 h

9: aq. LiOH / methanol / 2 h / 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; thionyl chloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 2945-08-6
methyl (4-nitrophenyl)acetate

: 783362-42-5
[4-(2-acetylamino-6-tert-butoxycarbonylamino-hexanoylamino)-phenyl]-hydroxy-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / NBS / CCl₄ / 5 h / Irradiation

2: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

3: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

4: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

5: 84 percent / HATU; collidine / dimethylformamide / 12 h

6: piperidine; TFA / dimethylformamide / 0.5 h

7: DIEA / CH₂Cl₂ / 1 h

8: aq. LiOH / methanol / 2 h / 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a