4-nitromandelic acid methyl ester acetate

Base Information

• Chemical Name: 4-nitromandelic acid methyl ester acetate
• CAS No.: 29704-42-5
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.211
• Mol file: 29704-42-5.mol

Synonyms:4-nitromandelic acid methyl ester acetate

Chemical Property of 4-nitromandelic acid methyl ester acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitromandelic acid methyl ester acetate

There total 6 articles about 4-nitromandelic acid methyl ester acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + p-nitrophenyldiazoacetic acetic anhydride (101137-77-3) → 4-nitromandelic acid methyl ester acetate (29704-42-5)

Guidance literature:

With dirhodium tetraacetate; In benzene; at 40 ℃; for 1h;

DOI:10.1021/jo060074e

Reference yield: 91.0%

methanol (67-56-1) + 4-nitrobenzaldehdye (555-16-8) + acetoxymalononitrile (6625-70-3) → 4-nitromandelic acid methyl ester acetate (29704-42-5)

Guidance literature:

With 1H-imidazole; at 20 ℃; for 3h;

DOI:10.1055/s-0028-1088044

Reference yield: 73.2%

sodium acetate (127-09-3) + bromo-(4-nitrophenyl)acetic acid methyl ester (85259-33-2) → 4-nitromandelic acid methyl ester acetate (29704-42-5)

Guidance literature:

In water; N,N-dimethyl-formamide; at 100 ℃; for 12h;

DOI:10.1039/b404471a

upstream raw materials:

methyl 2-diazo-2-(4-nitrophenyl)acetate

acetic acid

sodium acetate

bromo-(4-nitrophenyl)acetic acid methyl ester

Downstream raw materials:

methyl (±)-2-hydroxy-2-(4-nitrophenyl)acetate

methyl (±)-2-(4-aminophenyl)-2-hydroxyacetate

[4-(acetyl-Phe-amino)phenyl]-hydroxy-acetic acid methyl ester

[4-((S)-2-Acetylamino-3-phenyl-propionylamino)-phenyl]-hydroxy-acetic acid