3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

Base Information

Chemical Name:3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid
CAS No.:1142215-20-0
Molecular Formula:C₂₇H₂₉FO₄
Molecular Weight:436.523
Hs Code.:

Synonyms:3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

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Chemical Property of 3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

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Technology Process of 3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

There total 5 articles about 3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1142223-59-3
methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

: 1142215-20-0
3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 23 ℃; for 15h;
DOI:10.1021/ml300133f

Reference yield:

: 39778-63-7
3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester

: 1142215-20-0
3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 19 h / 23 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

6: sodium hydroxide / tetrahydrofuran; ethanol / 15 h / 23 °C

With dmap; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/ml300133f

Reference yield:

: 1142223-12-8
methyl 2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

: 1142215-20-0
3-[3-(2-(1,1-dimethyl-ethyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

4: sodium hydroxide / tetrahydrofuran; ethanol / 15 h / 23 °C

With lithium aluminium tetrahydride; thionyl chloride; caesium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml300133f