methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

Base Information

Chemical Name:methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate
CAS No.:1142223-59-3
Molecular Formula:C₂₈H₃₁FO₄
Molecular Weight:450.55
Hs Code.:

Synonyms:methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

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Chemical Property of methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

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Technology Process of methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

There total 5 articles about methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1142223-18-4
4-(chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 61389-68-2
methyl 3-(3-hydroxyphenyl)propionate

: 1142223-59-3
methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 19h;
DOI:10.1021/ml300133f

Reference yield:

: 1142223-10-6
methyl 3-tert-butyl-4-(trifluoromethylsulfonyloxy)benzoate

: 1142223-59-3
methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ml300133f

Reference yield:

: 39778-63-7
3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester

: 1142223-59-3
methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 19 h / 23 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C

With dmap; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/ml300133f