(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

Base Information

Chemical Name:(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol
CAS No.:133709-60-1
Molecular Formula:C₃₀H₄₂O₃Si
Molecular Weight:478.747
Hs Code.:

Synonyms:(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

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Chemical Property of (1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

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Technology Process of (1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

There total 14 articles about (1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 133709-58-7
(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

: 133709-60-1
(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

Guidance literature:: With potassium tri-sec-butyl-borohydride; In tetrahydrofuran; at -5 ℃; for 2h;

Reference yield:

: 17553-86-5,19576-08-0,20007-98-1,17553-89-8
(R)-7a-methyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione

: 133709-60-1
(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

Guidance literature:: Multi-step reaction with 14 steps

2: 26.9 percent / pyridine / Ambient temperature

3: 50percent HF / acetonitrile / Ambient temperature

4: pyridine / Ambient temperature

5: NaI / acetone / Heating

6: acetonitrile / Heating

7: t-BuOK / tetrahydrofuran

8: Br₂ / CCl₄

9: m-CPBA, NaOAc, NaHCO₃ / CH₂Cl₂ / Heating

10: Zn, CH₃COOH / methanol / Ambient temperature

11: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

12: imidazole / dimethylformamide / 0.25 h / Ambient temperature

13: 75 percent / PCC, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

14: 90 percent / K-selectride / tetrahydrofuran / 2 h / -5 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; potassium tert-butylate; bromine; sodium acetate; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; sodium iodide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 131556-98-4,131557-15-8
(RS)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxo-hexahydroindan-7-yl>-4-<(1,1-dimethylethyl)dimethylsilyloxy>butan-1-ol

: 133709-60-1
(1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol

Guidance literature:: Multi-step reaction with 13 steps

1: 26.9 percent / pyridine / Ambient temperature

2: 50percent HF / acetonitrile / Ambient temperature

3: pyridine / Ambient temperature

4: NaI / acetone / Heating

5: acetonitrile / Heating

6: t-BuOK / tetrahydrofuran

7: Br₂ / CCl₄

8: m-CPBA, NaOAc, NaHCO₃ / CH₂Cl₂ / Heating

9: Zn, CH₃COOH / methanol / Ambient temperature

10: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

11: imidazole / dimethylformamide / 0.25 h / Ambient temperature

12: 75 percent / PCC, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

13: 90 percent / K-selectride / tetrahydrofuran / 2 h / -5 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; potassium tert-butylate; bromine; sodium acetate; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; sodium iodide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;