133709-58-7

Basic information

• Product Name: (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene
• Synonyms: (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene
• CAS NO: 133709-58-7
• Molecular Weight: 476.731
• Mol File: 133709-58-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene(133709-58-7)
• EPA Substance Registry System: (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene(133709-58-7)

Safety Data

• Hazardous Substances Data: 133709-58-7(Hazardous Substances Data)

Upstream product

• 133709-52-1 (R)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxohexahydroindan-7-yl>-4-<<(4-methylphenyl)sulfonyl>oxy>butane-1-ol acetate 
• 133709-53-2 (R)-4-iodo-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxohexahydroindan-7-yl>butan-1-ol acetate 
• 133709-51-0 (R)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxohexahydroindan-7-yl>butane-1,4-diol-1-monoacetate 
• 133775-08-3 (R)-(4aR,10aR,10bR)-4a,7-methyl-3-oxo-2,3,4a,5,6,8,9,10,10a,10b-decahydro-1H-naphtho<2,1-b>pyran-10-ol acetate 
• 133775-07-2 (R)-(4aR,6aS,7S,10aS,10bR)-6a,7-dibromo-4a-methyl-3-oxo-dodecahydro-1H-naphtho<2,1-b>pyran-10-ol-acetate 
• 131557-06-7 Acetic acid (3aR,5aS,6S,9R,9aS,9bR)-5a,6-dibromo-3a-methyl-3-oxo-dodecahydro-cyclopenta[a]naphthalen-9-yl ester 
• 133709-56-5 (R)-(3aR,9aR,9bR)-1,2,3,3a,4,5,8,9,9a,9b-decahydro-3a-methyl-3-oxo-1H-benzoinden-9-ol-acetate 
• 133709-55-4 (R)-(1R,2R,8aR)-2-hydroxy-2-methyl-1-(3-hydroxypropyl)-1,2,3,4,6,7,8,8a-octahydronaphthalene-8-ol acetate 
• 131557-00-1 (R)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxo-hexahydroindan-7-yl>-4-<(1,1-dimethylethyl)dimethylsilyloxy>butan-1-ol acetate 
• 131556-98-4 (RS)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxo-hexahydroindan-7-yl>-4-<(1,1-dimethylethyl)dimethylsilyloxy>butan-1-ol 
• 17553-86-5 (R)-7a-methyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione 
• 133709-57-6 (1R,2R,8R,8aR)-2-methyl-1-<3-<(1,1-dimethylethyl)diphenylsilyloxy>propyl>-1,2,3,4,6,7,8,8a-octahydronaphthalene-2,8-diol 

Downstream Products

• 133709-60-1 (1S,7R,8R,8aR)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-7-methyl-1,2,3,5,6,7,8,8a-octahydro-naphthalene-1,7-diol 

Relevant articles and documents

Compactin from Hajos (-)-enedione

The hexahydronaphthalene portion of compactin was synthesized from the easily accessible (-)-enedione 8.Reductive alkylation employing tert-butyl copper hydride and 4-(tert-butyldimethylsilyloxy)-butanal leads to the epimeric acetates 10 and 14 in a ratio of 2:1.Both of them have been converted to a more advanced intermediate, the diacetate 21, which was transformed to 29 by dehydration, hydrogenation and allylic hydroxylation.Dehydration of 29 with Martin reagent has produced preferentially the desired diene 31, from which the target molecule 7 was obtained by partial hydrolysis.