methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

Base Information

Chemical Name:methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate
CAS No.:1227798-79-9
Molecular Formula:C₂₈H₂₇Br₂N₃O₁₀S
Molecular Weight:757.41
Hs Code.:

Synonyms:methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

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Chemical Property of methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

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Technology Process of methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

There total 8 articles about methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₄₅Br₂N₃O₁₀SSi₂

: 1227798-79-9
methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 2.25h; Inert atmosphere;
DOI:10.1016/j.tet.2013.10.057

Reference yield:

: 1227798-78-8
benzyl 2-methoxy-2-(trimethylsilyloxy)vinyl(trimethylsilyl)carbamate

: 1227798-77-7
5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methoxyisoquinoline

: 1227798-79-9
methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

Guidance literature:: benzyl 2-methoxy-2-(trimethylsilyloxy)vinyl(trimethylsilyl)carbamate; 5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methoxyisoquinoline; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 2.2h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/b926965g

Reference yield:

: 1227798-77-7
5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methoxyisoquinoline

: 1227798-79-9
methyl 2-(benzyloxycarbonylamino)-2-(5,8-dibromo-6,7-dimethoxy-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 2.25 h / 0 - 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; 1: |Mannich Aminomethylation;
DOI:10.1016/j.tet.2013.10.057