4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

Base Information

Chemical Name:4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide
CAS No.:701202-07-5
Molecular Formula:C₁₇H₁₆N₂O
Molecular Weight:264.327
Hs Code.:
DSSTox Substance ID:DTXSID501321654
ChEMBL ID:CHEMBL1481425

Synonyms:4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide;Maybridge3_002599;Oprea1_431073;MLS000860471;CHEMBL1481425;SCHEMBL17206287;DTXSID501321654;HMS1438G03;HMS2795M11;CCG-239271;IDI1_013986;701202-07-5;SMR000458555

Suppliers and Price of 4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:264.126263138
Heavy Atom Count:20
Complexity:351

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C2C=C(NC2=C1)C(=O)NC3=CC=CC=C3)C

Technology Process of 4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

There total 4 articles about 4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 383132-27-2
4,6-dimethyl-1H-indole-2-carboxylic acid

: 62-53-3
aniline

: 701202-07-5
4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

Guidance literature:: 4,6-dimethyl-1H-indole-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

aniline; With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm4003878

Reference yield: 67.0%

: 701202-07-5
4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 95264-40-7
4,6-dimethylindole-2-carboxylic acid ethyl ester

: 701202-07-5
4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; ethanol / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C

With ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In dichloromethane;
DOI:10.1021/jm4003878