2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

Base Information

Chemical Name:2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid
CAS No.:1297599-48-4
Molecular Formula:C₁₇H₁₂BrCl₂FN₂O₅
Molecular Weight:494.101
Hs Code.:

Synonyms:2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

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Chemical Property of 2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

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Technology Process of 2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

There total 7 articles about 2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 880348-30-1
3-bromo-4-fluoro-L-phenylalanine hydrochloride

: 77423-12-2
6,7-dichloro-1,2-dihydro-3,1-benzoxazine-2,4-dione

: 1297599-48-4
2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; chemoselective reaction;
DOI:10.1039/c0ob01004a

Reference yield:

: 880386-25-4
3-bromo-4-fluoro-L-phenylalanine

: 1297599-48-4
2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water / 0 °C

2: hydrogenchloride; water / 3 h / 100 °C

3: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; water; sodium hydrogencarbonate; triethylamine; In dichloromethane; water;
DOI:10.1039/c0ob01004a

Reference yield:

: 4-(3-bromo-4-fluorobenzylidene)-2-methyloxazol-5(4H)-one

: 1297599-48-4
2-{3-[2-(3-bromo-4-fluorophenyl)-1-carboxyethyl]ureido}-4,5-dichlorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: water; acetic acid / 1 h / 100 °C

2: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen / methanol / 24 h / 20 °C / 1551.49 Torr / Inert atmosphere

3: hydrogenchloride; water / 3 h / 100 °C

4: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; water; hydrogen; acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1039/c0ob01004a