3-bromo-4-fluoro-L-phenylalanine

Base Information

Chemical Name:3-bromo-4-fluoro-L-phenylalanine
CAS No.:880386-25-4
Molecular Formula:C₉H₉BrFNO₂
Molecular Weight:262.078
Hs Code.:

Synonyms:3-bromo-4-fluoro-L-phenylalanine

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Chemical Property of 3-bromo-4-fluoro-L-phenylalanine

Chemical Property:

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Technology Process of 3-bromo-4-fluoro-L-phenylalanine

There total 5 articles about 3-bromo-4-fluoro-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 880348-28-7
(S)-2-acetylamino-3-(3-bromo-4-fluorophenyl)propionic acid

: 880386-25-4
3-bromo-4-fluoro-L-phenylalanine

Guidance literature:: With acylase "Amano" enzyme; water; cobalt(II) chloride; potassium hydroxide; at 40 ℃; for 96h; pH=8; enantioselective reaction; Enzymatic reaction;
DOI:10.1039/c0ob01004a

Reference yield:

: 4-(3-bromo-4-fluorobenzylidene)-2-methyloxazol-5(4H)-one

: 880386-25-4
3-bromo-4-fluoro-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: water; acetic acid / 1 h / 100 °C

2: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen / methanol / 24 h / 20 °C / 1551.49 Torr / Inert atmosphere

3: acylase "Amano" enzyme; water; cobalt(II) chloride; potassium hydroxide / 96 h / 40 °C / pH 8 / Enzymatic reaction

With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; acylase "Amano" enzyme; water; hydrogen; acetic acid; cobalt(II) chloride; potassium hydroxide; In methanol;
DOI:10.1039/c0ob01004a

Reference yield:

: 2-acetylamino-3-(3-bromo-4-fluorophenyl)propionic acid

: 880386-25-4
3-bromo-4-fluoro-L-phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: water; isopropyl alcohol / 20 - 70 °C / Resolution of racemate

2: acylase "Amano" enzyme; water; cobalt(II) chloride; potassium hydroxide / 96 h / 40 °C / pH 8 / Enzymatic reaction

With acylase "Amano" enzyme; water; cobalt(II) chloride; potassium hydroxide; In water; isopropyl alcohol;
DOI:10.1039/c0ob01004a