4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

Base Information

Chemical Name:4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine
CAS No.:950525-67-4
Molecular Formula:C₁₆H₁₆N₄OS
Molecular Weight:312.395
Hs Code.:

Synonyms:4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

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Chemical Property of 4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

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Technology Process of 4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

There total 5 articles about 4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 950525-69-6
1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 950525-67-4
4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

Guidance literature:: 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone; N,N-dimethyl-formamide dimethyl acetal; at 90 ℃; for 20h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;
DOI:10.1134/S1070428020030239

Reference yield: 57.0%

: 950525-67-4
4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

Guidance literature:

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 950525-67-4
4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 20 °C

3.1: 20 h / 90 °C

3.2: 12 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;