1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone

Base Information

• Chemical Name: 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone
• CAS No.: 950525-69-6
• Molecular Formula: C₁₅H₁₆N₂O₂S
• Molecular Weight: 288.37
• Mol file: 950525-69-6.mol

Synonyms:1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone

Chemical Property of 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone

There total 2 articles about 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) + methyl 3-methoxy-5-methylbenzoate (108593-44-8) → 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone (950525-69-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

3-hydroxy-5-methylbenzoic acid (585-81-9) → 1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone (950525-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;

Reference yield: 79.0%

1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone (950525-69-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine (950525-67-4)

Guidance literature:

1-(3-methoxy-5-methylphenyl)-2-[2-methylsulfanylpyrimidin-4-yl)ethanone; N,N-dimethyl-formamide dimethyl acetal; at 90 ℃; for 20h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;

DOI:10.1134/S1070428020030239

upstream raw materials:

2-methylthio-4-methylpyrimidine

methyl 3-methoxy-5-methylbenzoate

3-hydroxy-5-methylbenzoic acid

Downstream raw materials:

4-[3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(methylsulfanyl)pyrimidine

[3-(3-methoxy-5-methylphenyl)-4-(2-methylthio-pyrimidin-4-yl)-pyrazol-1-yl]acetonitrile

[4-(2-methanesulfonylpyrimidin-4-yl)-3-(3-methoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

[4-[2-(3(S)-hydroxypyrrolidin-1-yl)-pyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile