Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:140679-80-7
Molecular Formula:C₃₁H₃₂N₂O₉S
Molecular Weight:608.669
Hs Code.:

Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Synonyms:Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 5 articles about Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 124-63-0
methanesulfonyl chloride

: 114551-14-3
5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)uracil

: 140679-80-7
Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With pyridine; for 2.75h; Ambient temperature;
DOI:10.1039/P19920000469

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 140679-80-7
Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine / 22 h / Ambient temperature

2: 1) pyridine / 1) 0 to 5 deg C, 1h, 2a) 0 to 5 deg C, 1h, 2b) RT, 2h

3: 84 percent / KOH, NaBH₄ / methanol / 23 h / Ambient temperature

4: 92 percent / pyridine / 2.75 h / Ambient temperature

With pyridine; potassium hydroxide; sodium tetrahydroborate; In methanol;
DOI:10.1039/P19920000469

Reference yield:

: 140679-68-1
2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester

: 140679-80-7
Methanesulfonic acid (2R,3S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / KOH, NaBH₄ / methanol / 23 h / Ambient temperature

2: 92 percent / pyridine / 2.75 h / Ambient temperature

With pyridine; potassium hydroxide; sodium tetrahydroborate; In methanol;
DOI:10.1039/P19920000469