N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide
CAS No.:811419-65-5
Molecular Formula:C₂₅H₂₅IN₂O₆S
Molecular Weight:608.454
Hs Code.:

N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

Synonyms:N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

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Chemical Property of N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

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Technology Process of N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

There total 8 articles about N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 811419-64-4
3-[(3aS,4R,5R,7aR)-2,2-Dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indole-2-carboxylic acid

: 811419-65-5
N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

Guidance literature:: With iodine; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1002/anie.200460218

Reference yield:

: 160309-18-2
(1R,4R,5S,6R)-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene

: 811419-65-5
N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / activated silica gel / 48 h / 70 °C

2: lithium hydroxide / tetrahydrofuran; H₂O / 14 h / 20 °C

3: 1.54 g / I₂; NaHCO₃ / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; iodine; silica gel; sodium hydrogencarbonate; In tetrahydrofuran; water; 3: Danishefsky iodolactonization;
DOI:10.1021/jo040292c

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 811419-65-5
N-((3aS,4S,4aR,11cR,12R,12aS)-4-Iodo-2,2-dimethyl-6-oxo-3a,4,4a,6,7,11c,12,12a-octahydro-1,3,5-trioxa-7-aza-indeno[5,6-c]fluoren-12-yl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / activated silica gel / 48 h / 70 °C

2: lithium hydroxide / tetrahydrofuran; H₂O / 14 h / 20 °C

3: 1.54 g / I₂; NaHCO₃ / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; iodine; silica gel; sodium hydrogencarbonate; In tetrahydrofuran; water; 3: Danishefsky iodolactonization;
DOI:10.1021/jo040292c