Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

Base Information

Chemical Name:Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester
CAS No.:852448-89-6
Molecular Formula:C₂₇H₃₀N₂O₆S
Molecular Weight:510.611
Hs Code.:

Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

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Chemical Property of Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

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Technology Process of Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

There total 1 articles about Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 63158-55-4
acetic acid 1H-indol-2-ylmethyl ester

: 160309-18-2
(1R,4R,5S,6R)-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene

: 852448-89-6
Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

Guidance literature:: With silica gel; at 20 ℃; for 16h;
DOI:10.1021/jo040292c

Reference yield:

: 852448-89-6
Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

: 811419-67-7
3-[(1aR,2R,3R,3aS,6aS,6bR)-5,5-Dimethyl-3-(toluene-4-sulfonylamino)-hexahydro-1,4,6-trioxa-cyclopropa[e]inden-2-yl]-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methoxide / methanol / 0.25 h / 20 °C

2.1: 21 mg / pyridinium chlorochromate / 1 h / 20 °C

3.1: sodium hypoclorite

4.1: 1.54 g / I₂; NaHCO₃ / tetrahydrofuran / 16 h / 20 °C

5.1: Li

5.2: 85 percent / 16 h / 20 °C

With sodium hypochlorite; iodine; sodium methylate; lithium; sodium hydrogencarbonate; pyridinium chlorochromate; In tetrahydrofuran; methanol; 4.1: Danishefsky iodolactonization;
DOI:10.1021/jo040292c

Reference yield:

: 852448-89-6
Acetic acid 3-[(3aS,4R,5R,7aR)-2,2-dimethyl-4-(toluene-4-sulfonylamino)-3a,4,5,7a-tetrahydro-benzo[1,3]dioxol-5-yl]-1H-indol-2-ylmethyl ester

: 811419-68-8
C₃₆H₄₄N₂O₁₁S

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methoxide / methanol / 0.25 h / 20 °C

2.1: 21 mg / pyridinium chlorochromate / 1 h / 20 °C

3.1: sodium hypoclorite

4.1: 1.54 g / I₂; NaHCO₃ / tetrahydrofuran / 16 h / 20 °C

5.1: Li

5.2: 85 percent / 16 h / 20 °C

6.1: 88 percent / NaH / tetrahydrofuran; various solvent(s) / 16 h / 40 °C

With sodium hypochlorite; iodine; sodium methylate; lithium; sodium hydride; sodium hydrogencarbonate; pyridinium chlorochromate; In tetrahydrofuran; methanol; 4.1: Danishefsky iodolactonization;
DOI:10.1021/jo040292c