3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

Base Information

Chemical Name:3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester
CAS No.:400648-64-8
Molecular Formula:C₃₄H₄₀Cl₂N₂O₅
Molecular Weight:627.608
Hs Code.:

Synonyms:3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

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Chemical Property of 3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

There total 6 articles about 3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400648-57-9
4-methoxy-3-nitrophenylacetic acid ethyl ester

: 400648-64-8
3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: H₂ / Pd/C / methanol

2.1: toluene / Heating

3.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

4.1: aq. HCl

5.1: NaBH(OAc)3 / methanol

6.1: Et₃N / CHCl₃

7.1: H₂ / Pd/C / methanol; ethyl acetate

8.1: Et₃N / CHCl₃

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2004.09.089

Reference yield:

: 824402-51-9
(4-Methoxy-3-{[1-phenyl-meth-(E)-ylidene]-amino}-phenyl)-acetic acid ethyl ester

: 400648-64-8
3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: aq. HCl

3.1: NaBH(OAc)3 / methanol

4.1: Et₃N / CHCl₃

5.1: H₂ / Pd/C / methanol; ethyl acetate

6.1: Et₃N / CHCl₃

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate;
DOI:10.1016/j.bmcl.2004.09.089

Reference yield:

: 400648-60-4
ethyl 2-(3-amino-4-methoxyphenyl)-3-(4-nitrophenyl)propanoate

: 400648-64-8
3-[4-(2,6-dichlorobenzoyl amino) phenyl]-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH(OAc)3 / methanol

2: Et₃N / CHCl₃

3: H₂ / Pd/C / methanol; ethyl acetate

4: Et₃N / CHCl₃

With hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium on activated charcoal; In methanol; chloroform; ethyl acetate;
DOI:10.1016/j.bmcl.2004.09.089