3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

Base Information

Chemical Name:3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester
CAS No.:400648-63-7
Molecular Formula:C₂₇H₃₈N₂O₄
Molecular Weight:454.61
Hs Code.:

Synonyms:3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

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Chemical Property of 3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

There total 6 articles about 3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{3-[(2,2-dimethylpropionyl)isobutyl amino]-4-methoxyphenyl}-3-(4-nitrophenyl)propionic acid ethyl ester

: 400648-63-7
3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

Guidance literature:: carbon palladium; In methanol; ethyl acetate;

Reference yield:

: 400648-62-6
2-{3-[(2,2-dimethyl-propionyl)-isobutyl-amino]-4-methoxy-phenyl}-3-(4-nitro-phenyl)-propionic acid ethyl ester

: 400648-63-7
3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/j.bmcl.2004.09.089

Reference yield:

: 400648-58-0
ethyl (3-amino-4-methoxyphenyl)acetate

: 400648-63-7
3-(4-aminophenyl)-2-{3-[(2,2-dimethylpropionyl)isobutylamino]-4-methoxyphenyl} propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / Heating

2.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 - 20 °C

3.1: aq. HCl

4.1: NaBH(OAc)3 / methanol

5.1: Et₃N / CHCl₃

6.1: H₂ / Pd/C / methanol; ethyl acetate

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2004.09.089