2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

Base Information

Chemical Name:2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol
CAS No.:594865-19-7
Molecular Formula:C₁₅H₁₇N₇O₃
Molecular Weight:343.345
Hs Code.:

2-[1-methyl-4-(4-nitro-benzylamino)-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-6-ylamino]-ethanol

Synonyms:2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

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Technology Process of 2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

There total 6 articles about 2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 141-43-5
ethanolamine

: 594865-11-9
(6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(4-nitro-benzyl)-amine

: 594865-19-7
2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

Guidance literature:: In dimethyl sulfoxide; butan-1-ol; at 90 ℃; for 12h;
DOI:10.1016/S0223-5234(03)00065-5

Reference yield:

: 85426-79-5
4-chloro-6-methylmercapto-1H-pyrazolo[3,4-d]pyrimidine

: 594865-19-7
2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / iPr₂NEt / butan-1-ol / 24 h / 50 °C

2: 88 percent / PPh₃; DEAD / tetrahydrofuran; CH₂Cl₂ / 3 h / 0 - 20 °C

3: 61 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 6 h / 0 - 20 °C

4: 40 percent / butan-1-ol; dimethylsulfoxide / 12 h / 90 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; butan-1-ol;
DOI:10.1016/S0223-5234(03)00065-5

Reference yield:

: 5334-26-9
4-hydroxy-6-methylmercapto-1H-pyrazolo[3,4-d]pyrimidine

: 594865-19-7
2-[1-methyl-4-(4-nitro-benzylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / POCl₃; PhNMe₂

2: 86 percent / iPr₂NEt / butan-1-ol / 24 h / 50 °C

3: 88 percent / PPh₃; DEAD / tetrahydrofuran; CH₂Cl₂ / 3 h / 0 - 20 °C

4: 61 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 6 h / 0 - 20 °C

5: 40 percent / butan-1-ol; dimethylsulfoxide / 12 h / 90 °C

With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; butan-1-ol;
DOI:10.1016/S0223-5234(03)00065-5