61203-48-3

Basic information

• Product Name: 4,5-DIMETHOXY-2-IODOBENZOIC ACID
• Synonyms: 4,5-DIMETHOXY-2-IODOBENZOIC ACID
• CAS NO: 61203-48-3
• Molecular Formula: C₉H₉IO₄
• Molecular Weight: 308.07
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 61203-48-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 206-208°C
• Boiling Point: 367.9 °C at 760 mmHg
• Flash Point: 176.3 °C
• Appearance: /
• Density: 1.79g/cm³
• Vapor Pressure: 4.62E-06mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.01±0.10(Predicted)
• CAS DataBase Reference: 4,5-DIMETHOXY-2-IODOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIMETHOXY-2-IODOBENZOIC ACID(61203-48-3)
• EPA Substance Registry System: 4,5-DIMETHOXY-2-IODOBENZOIC ACID(61203-48-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 61203-48-3(Hazardous Substances Data)

Usage

General Description

4,5-DIMETHOXY-2-IODOBENZOIC ACID is a chemical compound that belongs to the class of benzoic acids and derivatives. It is a white powder that is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical is known for its strong and efficient anti-inflammatory properties. It is also used in the production of agrochemicals and dyes. Additionally, 4,5-DIMETHOXY-2-IODOBENZOIC ACID is utilized in the manufacturing of various organic products such as cosmetics, fragrances, and flavors. It is important to handle it with care and follow proper safety precautions due to its potential health hazards.

InChI:InChI=1/C9H9IO4/c1-13-7-3-5(9(11)12)6(10)4-8(7)14-2/h3-4H,1-2H3,(H,11,12)

Upstream product

• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 173043-61-3 2-iodo-4,5-dimethoxybenzoic acid methyl ester 

Downstream Products

• 658710-27-1 N-(7-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 658710-29-3 N-(6-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 658710-33-9 N-(5-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 658710-32-8 N-(6-nitrocinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 738622-65-6 N-(quinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 658710-35-1 N-(cinnolin-4-yl)-N-[(2-N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 658710-25-9 N-(8-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 173043-61-3 2-iodo-4,5-dimethoxybenzoic acid methyl ester 
• 1144112-67-3 5-acetoxymethyl-2,3-dimethoxyphenyl 2-iodo-4,5-dimethoxybenzoate 
• 35241-23-7 6,7-dimethoxy-2-methylquinazoline-4(3H)-one 
• 371945-74-3 6,7-dimethoxy-2-phenylquinazolin-4(3Η)-one 
• 1295537-23-3 ethyl 2-(2-iodo-4,5-dimethoxybenzamido)acetate 
• 1295537-24-4 N-(2-hydroxyethyl)-2-iodo-4,5-dimethoxybenzamide 
• 1295537-26-6 (Z)-ethyl 4-(2-iodo-4,5-dimethoxybenzamido)but-2-enoate 

Relevant articles and documents

Copper-catalyzed domino reaction of carbodiimides and benzoic acid derivatives for the synthesis of quinazolinediones

Quinazolinediones were obtained from 2-iodobenzoic acids and carbodiimide derivatives under mild reaction conditions via a copper-catalyzed domino reaction. The absence of an external base was essential to avoid the generation of amide by-products. Both alkyl- and aryl-substituted carbodiimides gave the corresponding quinazolinediones. However, the use of aryl-substituted carbodiimides resulted in low yields due to an undesired elimination process.

Direct carbocyclizations of benzoic acids: Catalyst-controlled synthesis of cyclic ketones and the development of tandem aHH (acyl Heck-Heck) reactions

The formation of exo-methylene indanones and indenones from simple ortho-allyl benzoic acid derivatives has been developed. Selective formation of the indanone or indenone products in these reactions is controlled by choice of ancillary ligand. This new process has a low environmental footprint as the products are formed in high yields using low catalyst loadings, while the only stoichiometric chemical waste generated from the reactants in the transformation is acetic acid. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction, and utilized in the synthesis of donepezil. Carboxylic acids in aHH: Simple ortho-allyl benzoic acid derivatives have been utilized in an acyl Heck (aH) reaction to selectively form indanones and indenones. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction to form two sp 2-sp2 bonds of (E)-trisubstituted olefins.

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.