N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

Base Information

Chemical Name:N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide
CAS No.:1453068-67-1
Molecular Formula:C₃₀H₃₅F₆N₃O₄
Molecular Weight:615.616
Hs Code.:

N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

Synonyms:N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

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Chemical Property of N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

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Technology Process of N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

There total 11 articles about N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-67-1
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-66-0
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: With Chiralpak IC; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 1453068-67-1
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-66-0
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; ethanol / 24.25 h / 25 °C / Inert atmosphere

1.2: 2 h / 0 °C

1.3: 5 h / 0 - 25 °C

2.1: sodium hydroxide / ethyl acetate

3.1: triethylamine / ethyl acetate / 2 h / 0 °C

3.2: 60 h / 20 - 45 °C

4.1: ozone; oxygen / dichloromethane / -78 °C

4.2: 12 h / 25 °C / Inert atmosphere

5.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

6.1: Chiralpak IC / ethanol; hexane / Resolution of racemate

With methanol; sodium tetrahydroborate; oxygen; ozone; triethylamine; sodium hydroxide; In methanol; ethanol; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 1228573-50-9
N-[2-(benzyloxycarbonylamino)ethyl]pent-4-ynamide

: 1453068-67-1
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-66-0
N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 25 °C / Inert atmosphere

2.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

3.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

4.1: triethylamine / dichloromethane / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

5.2: 1.17 h / -78 - -30 °C

5.3: 0.5 h / -78 °C

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

7.1: triethylamine / ethyl acetate / 2 h / 0 °C

7.2: 60 h / 20 - 45 °C

8.1: ozone; oxygen / dichloromethane / -78 °C

8.2: 12 h / 25 °C / Inert atmosphere

9.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

10.1: Chiralpak IC / ethanol; hexane / Resolution of racemate

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; oxygen; ozone; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide;