1228573-50-9

Upstream product

• 6089-09-4 4-pentynoic acid 
• 72080-83-2 2-benzyloxycarbonylaminoethylamine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1228573-58-7 N-[2-(benzyloxycarbonylamino)ethyl]-5-(2-thienyl)lpent-4-ynamide 
• 1228573-59-8 N-[2-(benzyloxycarbonylamino)ethyl]-(3-thienyl)lpent-4-ynamide 
• 1228573-52-1 N-[2-(benzyloxycarbonylamino)ethyl]-5-phenylpent-4-ynamide 
• 1228573-56-5 N-[2-(benzyloxycarbonylamino)ethyl]-5-(p-chlorophenyl)pent-4-ynamide 
• 1228573-54-3 N-[2-(benzyloxycarbonylamino)ethyl]-5-(p-methoxyphenyl)pent-4-ynamide 
• 1453069-32-3 benzyl N-{2-[5-(2-methylphenyl)pent-4-ynamido]ethyl}carbamate 
• 1453069-69-6 (1S,8aS)-7,7-diallyl-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-70-9 (1S,8aS)-7,7-diallyl-N-(3-methoxy-5-(trifluoromethyl)benzyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-71-0 (1S,8aS)-7,7-diallyl-N-(3-chloro-5-(trifluoromethyl)benzyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-72-1 (1S,8aS)-7,7-diallyl-N-methyl-6-oxo-1-o-tolyl-N-(3-(trifluoromethyl)benzyl)hexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-75-4 (1S,8aS)-7,7-diallyl-N-(1-(3,5-bis(trifluoromethyl)phenyl)but-3-enyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-79-8 (1S,8aS)-7,7-diallyl-N-(1-(3,5-bis(trifluoromethyl)phenyl)propyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-86-7 (1S,8aS)-7,7-diallyl-N-methyl-N-((R)-1-(3-methyl-5-(trifluoromethyl)phenyl)ethyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-89-0 (1S,8aS)-7,7-diallyl-N-methyl-N-((S)-1-(3-methyl-5-(trifluoromethyl)phenyl)ethyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 

Relevant academic research and scientific papers

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd

A quick synthesis of 1-arylpyrrolopyrazinones from linear alkynylamide derivatives

A rapid synthesis of pyrrolopyrazinone derivatives based on formal double addition across the triple bond of appropriately substituted substrates is presented. The key cyclization step features the formation, mediated by [bis(trifluoroacetoxy)iodo]benzene -(PIFA), of a 5-aroylpyrrolidinone nucleus from appropriately func-t-ionalized N-protected N-(aminoethyl)amides. After removal of the protecting group, the free amino group is used to accomplish a second heterocyclization process onto the newly formed carbonyl group. By appropriate manipulation of these protecting groups and selection of reaction conditions, a series of pyrrolopyrazinones can be obtained in different stages of hydrogenation. Georg Thieme Verlag Stuttgart · New York.