(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

Base Information

Chemical Name:(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one
CAS No.:736933-40-7
Molecular Formula:C₂₈H₃₀O₄
Molecular Weight:430.544
Hs Code.:

Synonyms:(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

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Chemical Property of (2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

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Technology Process of (2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

There total 6 articles about (2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7348-71-2
(E)-1-bromo-2-pentene

: 736933-15-6
2-(benzhydryloxy)-1-(2,5-dimethoxyphenyl)-ethanone

: (2R)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

: 736933-40-7
(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

Guidance literature:: With cesium hydroxide; [O⁽⁹⁾-allyl-N-2',3',4'-trifluorobenzylhydrocinchonidinium]Br; In hexane; dichloromethane; at -35 ℃; for 4h; Title compound not separated from byproducts;
DOI:10.1021/ol0491235

Reference yield:

: 91-01-0
1,1-Diphenylmethanol

: 736933-40-7
(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / NaOH / tetrabutylammonium hydrogen sulfate / benzene; H₂O / 24 h / 20 °C

2.1: N,N-diisopropylethylamine; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 25 h / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 3 h / 0 °C

3.2: 2.24 g / tetrahydrofuran; hexane / 0.25 h / -40 °C

4.1: CsOH*H₂O / O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide / CH₂Cl₂; hexane / 4 h / -35 °C

With dmap; cesium hydroxide; sodium hydroxide; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; hexane; dichloromethane; water; benzene;
DOI:10.1021/jo051568z

Reference yield:

: 21409-25-6
Acetic acid,2-(diphenylmethoxy)

: 736933-40-7
(2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-diisopropylethylamine; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 25 h / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 3 h / 0 °C

2.2: 2.24 g / tetrahydrofuran; hexane / 0.25 h / -40 °C

3.1: CsOH*H₂O / O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide / CH₂Cl₂; hexane / 4 h / -35 °C

With dmap; cesium hydroxide; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo051568z