21409-25-6

Basic information

• Product Name: diphenylmethoxyacetic acid
• Synonyms: diphenylmethoxyacetic acid;2-(benzhydryloxy)acetic acid
• CAS NO: 21409-25-6
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 21409-25-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 99-100 °C
• Boiling Point: 377.8°Cat760mmHg
• Flash Point: 140.1°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 1.77E-07mmHg at 25°C
• Refractive Index: 1.584
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: diphenylmethoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethoxyacetic acid(21409-25-6)
• EPA Substance Registry System: diphenylmethoxyacetic acid(21409-25-6)

Safety Data

• Hazardous Substances Data: 21409-25-6(Hazardous Substances Data)

Usage

Uses

2-(diphenylmethoxy)acetic acid is a metabolite of diphenhydramine. Diphenhydramine is used in the treatment of numerous allergic ailments such as allergic rhinitis, asthma, anaphylaxis and others.

InChI:InChI=1/C15H14O3/c16-14(17)11-18-15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)

Upstream product

• 1204-50-8 benzhydrol sodium salt 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 91-01-0 1,1-Diphenylmethanol 
• 105-36-2 ethyl bromoacetate 
• 118286-11-6 ethyl 2-(benzhydryloxy)acetate 
• 79-14-1 glycolic Acid 

Downstream Products

• 736933-69-0 2-benzhydryloxy-N-methoxy-N-methyl-acetamide 
• 736933-40-7 (2S)-2-benzhydryloxy-1-(2,5-dimethoxy-phenyl)-hept-4-en-1-one 

Relevant articles and documents

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Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR3 and (Ar1)2CR4 is optionally substituted benzhydryl.

Asymmetric phase-transfer catalyzed glycolate alkylation, investigation of the scope, and application to the synthesis of (-)-ragaglitazar

Asymmetric glycolate alkylation using a protected acetophenone surrogate under solid-liquid phase-transfer conditions is a new approach to the synthesis of 2-hydroxy esters and acids. Diphenylmethyloxy-2,5-dimethoxyacetophenone 1 with a trifluorobenzyl ci