-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Base Information

Chemical Name:-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide
CAS No.:1026013-85-3
Molecular Formula:C₄₀H₅₂N₄O₈
Molecular Weight:716.875
Hs Code.:

<N-<1-(R)-<(1,1-dimethylethoxy)carbonyl>-3-<bis<(phenylmethoxy)carbonyl>amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Synonyms:-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

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Chemical Property of -3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

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Technology Process of -3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

There total 13 articles about -3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 69032-13-9
dibenzyl iminodicarboxylate

: -3-hydroxypropyl>-L-leucyl>-N-methyl-L-phenylalaninamide

: 1026013-85-3
-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 23 ℃; for 16h;
DOI:10.1021/jm00031a018

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 1026013-85-3
-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 18 h / 23 °C

2: 1.) trifluoromethanesulfonic anhydride, 1,8-bis(dimethylamino)naphthalene / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, dioxane, 21 deg C, 15 h

3: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2068.6 Torr

4: 43 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide / 15 h / 21 °C

5: 91 percent / aq. HOAc / 15 h / 5 °C

6: 35 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 16 h / 23 °C

With hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; acetic acid; 1-hydroxybenzotriazol-hydrate; trifluoromethanesulfonic acid anhydride; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00031a018

Reference yield:

: 328-38-1,21675-61-6,25248-98-0,70-45-1
(R)-leucine

: 1026013-85-3
-3-amino>propyl>-L-leucyl>-N-methyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaNO₂, H₂SO₄ 2.) aq. NaOH / 1.) water, from 0 deg C to 23 deg C, 5 h, 2.) methanol, 5 min

2: dimethylformamide / 18 h / 23 °C

3: 1.) trifluoromethanesulfonic anhydride, 1,8-bis(dimethylamino)naphthalene / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, dioxane, 21 deg C, 15 h

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2068.6 Torr

5: 43 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / dimethylformamide / 15 h / 21 °C

6: 91 percent / aq. HOAc / 15 h / 5 °C

7: 35 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 16 h / 23 °C

With sodium hydroxide; sulfuric acid; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; acetic acid; 1-hydroxybenzotriazol-hydrate; trifluoromethanesulfonic acid anhydride; dicyclohexyl-carbodiimide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00031a018