(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

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Chemical Name:(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester
CAS No.:185448-81-1
Molecular Formula:C₃₂H₄₇NO₇Si
Molecular Weight:585.813
Hs Code.:

Synonyms:(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

There total 3 articles about (S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 64263-81-6
N-(tert-butyloxycarbonyl)-N-methyl-O-(phenylmethyl)-L-tyrosine

: 185448-87-7
(S)-2-Hydroxy-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

: 185448-81-1
(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With dmap; Isopropenyl chloroformate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo9616062

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 185448-81-1
(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 65 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine, isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

With dmap; Isopropenyl chloroformate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1021/jo9616062

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 185448-81-1
(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 65 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine, isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

With dmap; Isopropenyl chloroformate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1021/jo9616062