(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

Base Information

Chemical Name:(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate
CAS No.:1310693-06-1
Molecular Formula:C₃₁H₃₅N₃O₂
Molecular Weight:481.638
Hs Code.:

Synonyms:(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

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Chemical Property of (S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

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Technology Process of (S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

There total 6 articles about (S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192539-86-8
5-isobutyl-7-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

: 1310693-06-1
(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: propionic acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; propionic acid; triphenylphosphine; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; 2: Mitsunobu reaction / 3: Suzuki coupling;
DOI:10.1021/jm200409s

Reference yield:

: 1038919-63-9
(R)-5-bromo-2,3-dihydro-1H-inden-1-ol

: 1310693-06-1
(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm200409s

Reference yield:

: 1310692-69-3
2-amino-6-isobutyl-4-methylnicotinamide

: 1310693-06-1
(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(acetoxy)iodo]benzene; potassium hydroxide / methanol / 0 - 25 °C

2: propionic acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; sodium carbonate; propionic acid; triphenylphosphine; potassium hydroxide; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Hofmann rearrangement / 3: Mitsunobu reaction / 4: Suzuki coupling;
DOI:10.1021/jm200409s