(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

Base Information

Chemical Name:(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid
CAS No.:1310692-67-1
Molecular Formula:C₂₉H₃₁N₃O₂
Molecular Weight:453.584
Hs Code.:

Synonyms:(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

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Chemical Property of (S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

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Technology Process of (S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

There total 8 articles about (S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1310693-06-1
(S)-ethyl 2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoate

: 1310692-67-1
(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 100 ℃; for 24h;
DOI:10.1021/jm200409s

Reference yield:

: 1192539-86-8
5-isobutyl-7-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

: 1310692-67-1
(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: propionic acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

4: sodium hydroxide / methanol; water / 24 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; propionic acid; triphenylphosphine; sodium hydroxide; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2: Mitsunobu reaction / 3: Suzuki coupling;
DOI:10.1021/jm200409s

Reference yield:

: 1310692-69-3
2-amino-6-isobutyl-4-methylnicotinamide

: 1310692-67-1
(S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: [bis(acetoxy)iodo]benzene; potassium hydroxide / methanol / 0 - 25 °C

2: propionic acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

5: sodium hydroxide / methanol; water / 24 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; sodium carbonate; propionic acid; triphenylphosphine; potassium hydroxide; sodium hydroxide; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Hofmann rearrangement / 3: Mitsunobu reaction / 4: Suzuki coupling;
DOI:10.1021/jm200409s