(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

Base Information

Chemical Name:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide
CAS No.:1286280-54-3
Molecular Formula:C₁₇H₁₉NO₃S
Molecular Weight:317.409
Hs Code.:

Synonyms:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

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Chemical Property of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

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Technology Process of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

There total 4 articles about (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1286280-53-2
(1S,2S)-2-thiophen-2yl-cyclopropanecarboxylic chloride

: 100929-33-7
(R)-2-amino-2-(4-methoxyphenyl)-1-ethanol

: 1286280-54-3
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 1286280-54-3
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tert-butylhypochlorite / propan-1-ol / 0.13 h / 20 °C

1.2: 0.13 h / 0 °C

1.3: 1.5 h / 0 °C

2.1: hydrogen / palladium on carbon / methanol / 1.5 h / 760.05 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With tert-butylhypochlorite; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium on carbon; In methanol; propan-1-ol; dichloromethane;

Reference yield:

: 199392-93-3
Benzyl (R)-2-hydroxy-1-(4-methoxyphenyl)ethylcarbamate

: 1286280-54-3
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-2-hydroxy-1-(4-methoxy-phenyl)ethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on carbon / methanol / 1.5 h / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on carbon; In methanol; dichloromethane;