2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

Base Information

Chemical Name:2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid
CAS No.:1262007-19-1
Molecular Formula:C₂₆H₂₇F₃N₂O₃
Molecular Weight:472.507
Hs Code.:

Synonyms:2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

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Chemical Property of 2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

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Technology Process of 2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

There total 6 articles about 2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₂₇H₂₉F₃N₂O₃

: 1262007-19-1
2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.11.089

Reference yield:

: 20776-45-8
5-benzyloxytryptamine

: 1262007-19-1
2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / water; acetonitrile / 80 °C

2: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran

3: tetrahydrofuran / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5: hydrogenchloride / 1,4-dioxane / 20 °C

6: lithium hydroxide / 1,4-dioxane / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; caesium carbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; 1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.bmcl.2014.11.089

Reference yield:

: 1262007-84-0
methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

: 1262007-19-1
2-(6-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran

2: tetrahydrofuran / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: lithium hydroxide / 1,4-dioxane / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.11.089