(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate
CAS No.:1445985-74-9
Molecular Formula:C₂₃H₂₂Cl₂F₃N₃O₄S₂
Molecular Weight:596.479
Hs Code.:

Synonyms:(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

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Chemical Property of (R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

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Technology Process of (R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

There total 11 articles about (R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 381229-84-1
2,5-dichloro-4-formylphenyl trilluoromethanesulfonate

: 1445985-74-9
(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

Guidance literature:: With sodium tris(acetoxy)borohydride; at 20 ℃; for 18h;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-74-9
(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: sodium tris(acetoxy)borohydride / 18 h / 20 °C

With hydrogenchloride; borane-THF; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-74-9
(R)-2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride / 18 h / 20 °C

With hydrogenchloride; borane-THF; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;