1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

Base Information

Chemical Name:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide
CAS No.:1255714-66-9
Molecular Formula:C₁₉H₂₄F₃N₃O₃
Molecular Weight:399.413
Hs Code.:

Synonyms:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

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Chemical Property of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

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Technology Process of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

There total 5 articles about 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 107-10-8,42939-71-9
propylamine

: 1255650-21-5
2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 503-38-8
trichloromethyl chloroformate

: 1255714-66-9
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

Guidance literature:: 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one; trichloromethyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃;

propylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1255714-66-9
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylaluminum chloride / hexane; toluene / 20 °C / Inert atmosphere; Reflux

1.2: 20 °C

2.1: triethylamine / dichloromethane / 0 °C

2.2: 16 h / 20 °C

With dimethylaluminum chloride; triethylamine; In hexane; dichloromethane; toluene;

Reference yield:

: 1255650-19-1
1-benzyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

: 1255714-66-9
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylaluminum chloride / n-heptane; toluene / 20 °C / Inert atmosphere; Reflux

2.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 3 h / 20 °C

3.1: sodium hydroxide / water

4.1: triethylamine / dichloromethane / 0 °C

4.2: 16 h / 20 °C

With hydrogen; dimethylaluminum chloride; triethylamine; sodium hydroxide; 20% palladium hydroxide-activated charcoal; In methanol; n-heptane; dichloromethane; water; toluene;