2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

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Chemical Name:2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione
CAS No.:1177558-60-9
Molecular Formula:C₂₉H₃₃NO₃Si
Molecular Weight:471.671
Hs Code.:

Synonyms:2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

There total 6 articles about 2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1177558-51-8
[3-({[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}methyl)phenyl]boronic acid

: 1177558-41-6
2-[(3-bromo-5-methylphenyl)methyl]-1H-isoindole-1,3(2H)-dione

: 1177558-60-9
2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: 2-[(3-bromo-5-methylphenyl)methyl]-1H-isoindole-1,3(2H)-dione; With potassium carbonate; triphenylphosphine; palladium diacetate; In 1,4-dioxane; at 60 ℃; for 0.166667h;

[3-({[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}methyl)phenyl]boronic acid; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 556-96-7
5-bromo-1,3-xylene

: 1177558-60-9
2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 7 h / Reflux

2.1: N,N-dimethyl-formamide / 2 h / Reflux

3.1: potassium carbonate; triphenylphosphine / palladium diacetate / 1,4-dioxane / 0.17 h / 60 °C / Inert atmosphere

3.2: 100 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; triphenylphosphine; dibenzoyl peroxide; palladium diacetate; In 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling / 3.2: Suzuki Coupling;

Reference yield:

: 15852-73-0
(3-Bromophenyl)methanol

: 1177558-60-9
2-{[3'-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-methyl-3-biphenylyl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h / 0 °C / pH 4 - 5

3.1: potassium carbonate; triphenylphosphine / palladium diacetate / 1,4-dioxane / 0.17 h / 60 °C / Inert atmosphere

3.2: 100 °C

With dmap; n-butyllithium; potassium carbonate; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 3.1: Suzuki Coupling / 3.2: Suzuki Coupling;