(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

Base Information

Chemical Name:(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone
CAS No.:1344666-98-3
Molecular Formula:C₂₇H₂₁FN₆O₄S
Molecular Weight:544.566
Hs Code.:

Synonyms:(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

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Chemical Property of (7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

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Technology Process of (7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

There total 9 articles about (7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344666-97-2
[5-(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-6-fluoro-pyridin-2-yl]-(6-methoxy-pyridin-3-yl)-carbamic acid tert-butyl ester

: 1344666-98-3
(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

Guidance literature:: [5-(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-6-fluoro-pyridin-2-yl]-(6-methoxy-pyridin-3-yl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 0.75h;

With potassium carbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: 171178-50-0
2,6-difluoronicotinic acid

: 1344666-98-3
(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / Reflux

1.2: pH ~ 9

2.1: triethylamine / N,N-dimethyl-formamide / -40 - 70 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

3.2: 1 h

4.1: Dess-Martin periodane / tetrahydrofuran / 0.5 h / 20 °C

5.1: dmap / tetrahydrofuran / 20 °C

6.1: isopropylmagnesium chloride / tetrahydrofuran / 1.25 h / -40 - -5 °C / Inert atmosphere

6.2: 2 h / -45 - 20 °C

7.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

8.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.75 h / 80 °C

With dmap; lithium aluminium tetrahydride; sulfuric acid; isopropylmagnesium chloride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 117671-02-0
methyl 2,6-difluoro-3-pyridinecarboxylate

: 1344666-98-3
(7-benzenesulfonyl-4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[2-fluoro-6-(6-methoxy-pyridin-3-ylamino)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / N,N-dimethyl-formamide / -40 - 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2.2: 1 h

3.1: Dess-Martin periodane / tetrahydrofuran / 0.5 h / 20 °C

4.1: dmap / tetrahydrofuran / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.25 h / -40 - -5 °C / Inert atmosphere

5.2: 2 h / -45 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

7.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.75 h / 80 °C

With dmap; lithium aluminium tetrahydride; isopropylmagnesium chloride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;