2,6-Difluoronicotinic acid

Base Information

Chemical Name:2,6-Difluoronicotinic acid
CAS No.:171178-50-0
Molecular Formula:C6H3F2NO2
Molecular Weight:159.092
Hs Code.:2933399090
European Community (EC) Number:871-870-4
DSSTox Substance ID:DTXSID40441993
Nikkaji Number:J1.403.907D
Wikidata:Q72464202
Mol file:171178-50-0.mol

Synonyms:2,6-Difluoronicotinic acid;171178-50-0;2,6-difluoropyridine-3-carboxylic Acid;2,6-difluoro-3-pyridinecarboxylic acid;MFCD08064047;3-PYRIDINECARBOXYLIC ACID, 2,6-DIFLUORO-;2,6 difluoronicotinic acid;2,6-Difluoro-nicotinic acid;SCHEMBL445478;DTXSID40441993;IEVMFAWRTJEFCF-UHFFFAOYSA-N;BBL103387;STL557197;2,6-difluoropyridine-3-carboxylicAcid;AKOS005257093;AB43522;AM84600;PS-6921;AC-25633;SY022256;CS-0091204;FT-0657955;EN300-98841;S11311;A811303;J-507479;Z1201624415

Suppliers and Price of 2,6-Difluoronicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,6-Difluoronicotinicacid
250mg
$ 55.00

SynQuest Laboratories
2,6-Difluoronicotinic acid
5 g
$ 96.00

SynQuest Laboratories
2,6-Difluoronicotinic acid
25 g
$ 192.00

SynQuest Laboratories
2,6-Difluoronicotinic acid
100 g
$ 576.00

Matrix Scientific
2,6-Difluoropyridine-3-carboxylic acid 97%
100g
$ 358.00

Matrix Scientific
2,6-Difluoropyridine-3-carboxylic acid 97%
25g
$ 99.00

Matrix Scientific
2,6-Difluoropyridine-3-carboxylic acid 97%
5g
$ 24.00

Frontier Specialty Chemicals
2,6-Difluoronicotinicacid 98%
25g
$ 75.00

Frontier Specialty Chemicals
2,6-Difluoronicotinicacid 98%
5g
$ 20.00

Frontier Specialty Chemicals
2,6-Difluoronicotinicacid 98%
100g
$ 200.00

Total 41 raw suppliers

Chemical Property of 2,6-Difluoronicotinic acid

Chemical Property:

Melting Point:165-167 °C
Boiling Point:304.695 °C at 760 mmHg
PKA:2.48±0.10(Predicted)
Flash Point:138.075 °C
PSA：50.19000
Density:1.536 g/cm³
LogP:1.05800
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:159.01318466
Heavy Atom Count:11
Complexity:165

Purity/Quality:

98% ^*data from raw suppliers

2,6-Difluoronicotinicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=NC(=C1C(=O)O)F)F

Technology Process of 2,6-Difluoronicotinic acid

There total 8 articles about 2,6-Difluoronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1513-65-1
2,6-difluoro pyridine

: 171178-50-0
2,6-difluoronicotinic acid

Guidance literature:: With CO₂; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane;

Reference yield: 94.0%

: 1513-65-1
2,6-difluoro pyridine

: 124-38-9,18923-20-1
carbon dioxide

: 171178-50-0
2,6-difluoronicotinic acid

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1002/ejoc.200300649

Reference yield: 85.0%

: 1513-65-1
2,6-difluoro pyridine

: 24424-99-5
di-tert-butyl dicarbonate

: 171178-50-0
2,6-difluoronicotinic acid

Guidance literature:: 2,6-difluoro pyridine; di-tert-butyl dicarbonate; With lithium diisopropyl amide; In tetrahydrofuran; at -15 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 40 ℃; pH=1 - 2; Inert atmosphere;