(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Base Information

Chemical Name:(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol
CAS No.:1026910-84-8
Molecular Formula:C₂₄H₂₀F₃NO₃
Molecular Weight:427.423
Hs Code.:

Synonyms:(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Suppliers and Price of (E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

There total 14 articles about (E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026506-69-3
(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-enoic acid ethyl ester

: 1026910-84-8
(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1026910-84-8
(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1.1: HCl / ethyl acetate

2.1: POCl₃ / CHCl₃

3.1: CHCl₃

4.1: NaOMe / ethanol

5.1: NaBH₄ / methanol; tetrahydrofuran

6.1: Et₃SiH; TFA / CH₂Cl₂

7.1: dimethylformamide

8.1: Al-Ni; 70percent aq. formic acid

9.1: tetrahydrofuran / 0.83 h / 0 - 20 °C

10.1: Jones reagent / acetone / 0.5 h / 10 °C

11.1: NaH / toluene / 1 h

11.2: toluene; tetrahydrofuran / 48 h

12.1: DIBAL / diethyl ether / 0.5 h / -78 °C

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; jones reagent; sodium methylate; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 1.1: Condensation / 2.1: deoxygenation / 3.1: Bromination / 4.1: Condensation / 5.1: Reduction / 6.1: Reduction / 7.1: cyanidation / 8.1: Reduction / 9.1: Grignard reaction / 10.1: Oxidation / 11.1: Metallation / 11.2: Condensation / 12.1: Reduction;
DOI:10.1021/jm990476x

Reference yield:

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 1026910-84-8
(E)-3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaOMe / ethanol

2.1: NaBH₄ / methanol; tetrahydrofuran

3.1: Et₃SiH; TFA / CH₂Cl₂

4.1: dimethylformamide

5.1: Al-Ni; 70percent aq. formic acid

6.1: tetrahydrofuran / 0.83 h / 0 - 20 °C

7.1: Jones reagent / acetone / 0.5 h / 10 °C

8.1: NaH / toluene / 1 h

8.2: toluene; tetrahydrofuran / 48 h

9.1: DIBAL / diethyl ether / 0.5 h / -78 °C

With triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; jones reagent; sodium methylate; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 1.1: Condensation / 2.1: Reduction / 3.1: Reduction / 4.1: cyanidation / 5.1: Reduction / 6.1: Grignard reaction / 7.1: Oxidation / 8.1: Metallation / 8.2: Condensation / 9.1: Reduction;
DOI:10.1021/jm990476x