2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Base Information

Chemical Name:2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate
CAS No.:1259436-29-7
Molecular Formula:C₄₁H₅₄N₄O₆
Molecular Weight:698.903
Hs Code.:

2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Synonyms:2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

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Chemical Property of 2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

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Technology Process of 2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

There total 7 articles about 2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259436-28-6
4-[2-(dibenzylamino)ethyl]-2,7-dimethyl-6-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

: 543-27-1
isobutyl chloroformate

: 1259436-29-7
2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Guidance literature:: 4-[2-(dibenzylamino)ethyl]-2,7-dimethyl-6-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid; isobutyl chloroformate; With triethylamine; In tetrahydrofuran; for 1h; Inert atmosphere; Cooling with ice;

With sodium tetrahydroborate; ethanol; In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield:

: 1259436-23-1
2-Methyl-2-propanyl (3R)-3-[{[2-methyl-5-nitro-4-(2-propen-1-yloxy)phenyl]carbonyl}(2-propanyl)amino]-1-piperidinecarboxylate

: 1259436-29-7
2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.42 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

3.1: acetic acid; iron / 10 h / 90 °C

4.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 80 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 60 °C

5.2: 20 °C

6.1: triethylamine / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

6.2: 1 h / Cooling with ice

With morpholine; 18-crown-6 ether; lithium hydroxide monohydrate; water; iron; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1259436-25-3
2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

: 1259436-29-7
2-methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]-2-(hydroxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2.1: acetic acid; iron / 10 h / 90 °C

3.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 60 °C

4.2: 20 °C

5.1: triethylamine / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

5.2: 1 h / Cooling with ice

With 18-crown-6 ether; lithium hydroxide monohydrate; water; iron; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;