2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

Base Information

Chemical Name:2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate
CAS No.:1259436-25-3
Molecular Formula:C₂₁H₃₁N₃O₆
Molecular Weight:421.494
Hs Code.:

Synonyms:2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

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Chemical Property of 2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

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Technology Process of 2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

There total 1 articles about 2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259436-23-1
2-Methyl-2-propanyl (3R)-3-[{[2-methyl-5-nitro-4-(2-propen-1-yloxy)phenyl]carbonyl}(2-propanyl)amino]-1-piperidinecarboxylate

: 1259436-25-3
2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.416667h;

Reference yield:

: 29263-94-3
diethyl bromomethylmalonate

: 1259436-25-3
2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

: 1163283-26-8
diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield:

: 1259436-25-3
2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

: 1259436-27-5
2-Methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]2-(methoxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2.1: acetic acid; iron / 10 h / 90 °C

3.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 60 °C

4.2: 20 °C

5.1: triethylamine / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

5.2: 1 h / Cooling with ice

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 20 °C / Cooling with ice

With 18-crown-6 ether; lithium hydroxide monohydrate; water; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;