(S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide

Base Information

• Chemical Name: (S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide
• CAS No.: 910910-13-3
• Molecular Formula: C₁₇H₃₃NOSSi
• Molecular Weight: 327.607

Synonyms:(S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide

Chemical Property of (S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide

There total 2 articles about (S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-(+)-N-(1-cyclohexyl-ethylidene)-2-methyl-2-propanesulfinamide + trimethylsilylacetylene (1066-54-2) → (SS,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide (910910-13-3)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.25h;

(S)-(+)-N-(1-cyclohexyl-ethylidene)-2-methyl-2-propanesulfinamide; With trimethylaluminum; In hexane; toluene; at -78 - 20 ℃;

DOI:10.1021/jo061160h

Reference yield:

Cyclohexyl methyl ketone (823-76-7) → (SS,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide (910910-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 83 percent / Ti(OEt)4 / tetrahydrofuran / Heating

2.1: butyllithium / toluene; hexane / 0.25 h / -78 °C

2.2: 73 percent / Me₃Al / toluene; hexane / -78 - 20 °C

With titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/jo061160h

Reference yield: 74.0%

(SS,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide (910910-13-3) → (Ss,S)-N-(1-cyclohexyl-1-methylprop-2-ynyl)-2-methylpropanesulfinamide (913981-91-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm060701s

upstream raw materials:

trimethylsilylacetylene

Cyclohexyl methyl ketone

Downstream raw materials:

(Ss,S)-N-(1-cyclohexyl-1-methylprop-2-ynyl)-2-methylpropanesulfinamide

Thiophene-3-carboxylic acid {(S)-1-[1-((S)-1-carbamoyl-pentyl)-1H-[1,2,3]triazol-4-yl]-1-cyclohexyl-ethyl}-amide

N-{1-[1-(1-carbamoyl-pentyl)-1H-[1,2,3]triazol-4-yl]-1-cyclohexyl-ethyl}-benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 910910-13-3 (S_S,S)-(+)-N-(1-cyclohexyl-1-methyl-3-(trimethylsilanyl)-prop-2-ynyl)-2-methyl-2-propanesulfinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send