lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

Base Information

Chemical Name:lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate
CAS No.:1321844-72-7
Molecular Formula:C₂₈H₁₈N₃O*Li
Molecular Weight:419.411
Hs Code.:

Synonyms:lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

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Chemical Property of lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

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Technology Process of lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

There total 9 articles about lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1321844-70-5
5-[4-(1-Phenyl-1H-benzimidazol-2-yl)phenyl]quinolin-8-ol

: 1321844-72-7
lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

Guidance literature:: With n-butyllithium; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1321844-72-7
lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Oxone / N,N-dimethyl-formamide / 20 - 40 °C / Inert atmosphere

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / Reflux

3.1: toluene; 1,4-dioxane / 0.5 h

3.2: 8 h / 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h

5.1: n-butyllithium / acetonitrile / 1 h / 20 °C

With Oxone; n-butyllithium; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 13207-63-1
5-iodoquinolin-8-ol

: 1321844-72-7
lithium 5-[4-(1-phenyl-1H-benzimidazol-2-yl)-phenyl]-8-hydroxy-quinolate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / Inert atmosphere

2.1: toluene; 1,4-dioxane / 0.5 h

2.2: 8 h / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h

4.1: n-butyllithium / acetonitrile / 1 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile; 2.1: Suzuki Coupling;