benzyl-(1-amino-3-chloro-2-propanol)

Base Information

• Chemical Name: benzyl-(1-amino-3-chloro-2-propanol)
• CAS No.: 75605-52-6
• Molecular Formula: C10H14 Cl N O
• Molecular Weight: 199.68
• Hs Code.: 2922199090
• Mol file: 75605-52-6.mol

Synonyms:1-(Benzylamino)-3-chloro-2-propanol;3-(Benzylamino)-1-chloro-2-propanol

Chemical Property of benzyl-(1-amino-3-chloro-2-propanol)

Chemical Property:

• Vapor Pressure: 2.53E-05mmHg at 25°C
• Boiling Point: 344.3°C at 760 mmHg
• Flash Point: 162°C
• PSA: 32.26000
• Density: 1.151g/cm³
• LogP: 1.76680

Purity/Quality:

99% ^*data from raw suppliers

1-(Benzylamino)-3-chloropropan-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl-(1-amino-3-chloro-2-propanol)

There total 3 articles about benzyl-(1-amino-3-chloro-2-propanol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzylamine (100-46-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → N-benzyl-3-amino-1-chloropropan-2-ol (75605-52-6,278788-93-5)

Guidance literature:

With calcium(II) trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(03)00292-8

Reference yield: 83.0%

→ N-benzyl-3-amino-1-chloropropan-2-ol (75605-52-6,278788-93-5)

Guidance literature:

Reference yield:

benzylamine (100-46-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-benzylamino-3-chloro-propan-1-ol + N-benzyl-3-amino-1-chloropropan-2-ol (75605-52-6,278788-93-5)

Guidance literature:

With lithium bromide; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1258510

upstream raw materials:

benzylamine

epichlorohydrin

Downstream raw materials:

N-benzyl-3-(trimethylsilyloxy)azetidine

1-benzyl-3-(triisopropylsiloxy)azetidine

1-benzyl-3-(triethylsiloxy)azetidine

1-benzyl-(3-chloro-2-trimethylsilyloxypropyl)-amine