benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

Base Information

• Chemical Name: benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide
• CAS No.: 115569-69-2
• Molecular Formula: C₂₃H₂₂N₄O₅S
• Molecular Weight: 466.517
• Mol file: 115569-69-2.mol

Synonyms:benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

Chemical Property of benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

There total 4 articles about benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.72%

benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide (115546-69-5) + acetylene (74-86-2,25067-58-7) → benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide (115569-69-2)

Guidance literature:

In acetone; at 85 ℃; for 24h;

DOI:10.1016/0223-5234(94)90139-2

Reference yield:

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate (115546-67-3) → benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide (115569-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / dimethylformamide; H₂O / 4 h / 60 - 65 °C

2: glacial acetic acid, KMnO₄ / H₂O / 3 h / Ambient temperature

3: 79.72 percent / acetone / 24 h / 85 °C

With potassium permanganate; sodium azide; acetic acid; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/0223-5234(94)90139-2

Reference yield:

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide → benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide (115569-69-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 67.92 percent / pyridine, phosphorus pentasulfide / CH₂Cl₂ / 18 h / Ambient temperature

2: sodium azide / dimethylformamide; H₂O / 4 h / 60 - 65 °C

3: glacial acetic acid, KMnO₄ / H₂O / 3 h / Ambient temperature

4: 79.72 percent / acetone / 24 h / 85 °C

With pyridine; diphosphorus pentasulfide; potassium permanganate; sodium azide; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/0223-5234(94)90139-2

upstream raw materials:

benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

acetylene

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate