benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

Base Information

• Chemical Name: benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate
• CAS No.: 115546-68-4
• Molecular Formula: C₂₁H₂₀N₄O₃S
• Molecular Weight: 408.481
• Mol file: 115546-68-4.mol

Synonyms:benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

Chemical Property of benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

There total 2 articles about benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate (115546-67-3) → benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate (115546-68-4)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 60 - 65 ℃; for 4h;

DOI:10.1016/0223-5234(94)90139-2

Reference yield:

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide → benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate (115546-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 67.92 percent / pyridine, phosphorus pentasulfide / CH₂Cl₂ / 18 h / Ambient temperature

2: sodium azide / dimethylformamide; H₂O / 4 h / 60 - 65 °C

With pyridine; diphosphorus pentasulfide; sodium azide; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(94)90139-2

Reference yield:

benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate (115546-68-4) → benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide (115546-69-5)

Guidance literature:

With potassium permanganate; acetic acid; In water; for 3h; Yield given; Ambient temperature;

DOI:10.1016/0223-5234(94)90139-2

upstream raw materials:

benzhydryl 2α-chloromethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate

Downstream raw materials:

benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide