alpha-aminopimelic acid

Base Information

• Chemical Name: alpha-aminopimelic acid
• CAS No.: 3721-85-5
• Molecular Formula: C₇H₁₃NO₄
• Molecular Weight: 175.185
• Mol file: 3721-85-5.mol

Synonyms:Heptanedioicacid, 2-amino-, (?à)-;Heptanedioic acid, 2-amino-, DL- (8CI); (?à)-2-Aminoheptanedioic acid; 2-Aminoheptanedioic acid;2-Aminopimelic acid; DL-2-Aminoheptanedioic acid; DL-2-Aminopimelic acid; DL-a-Aminopimelic acid; NSC 402480; a-Aminopimelic acid

Chemical Property of alpha-aminopimelic acid

Chemical Property:

• Boiling Point: 378.5°Cat760mmHg
• Flash Point: 182.7°C
• PSA: 100.62000
• Density: 1.275g/cm³
• LogP: 0.74360

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-aminopimelic acid

There total 47 articles about alpha-aminopimelic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-L-N-Boc aminopimelic acid (115573-33-6) → (2S)-L-α-Aminopimelic acid (26630-55-7,3721-85-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)90305-9

Reference yield: 83.0%

(2RS)-α-Ethyl ω-methyl 2-(N-acetylamino)pimelate (156387-02-9) → D-2-aminoadipic acid (7620-28-2) + D-alpha-Aminopimelic acid (32224-57-0,3721-85-5)

Guidance literature:

With hydrogenchloride; In diethylene glycol dimethyl ether; for 48h; Yields of byproduct given; Heating;

DOI:10.1021/jo00092a029

Reference yield:

2-oxoheptane-1,7-dioate (17126-90-8) → alpha-aminopimelic acid (627-76-9,3721-85-5)

Guidance literature:

With L-alanin; pyridoxal 5'-phosphate; E_.coli TOP₁₀/pBAD-Psy_AT; at 37 ℃; for 24h; pH=7; Product distribution / selectivity; Potassium phosphate buffer; Enzymatic reaction;

upstream raw materials:

alpha-aminopimelic acid

(R)-2-(N-(phenylsulfonyl)amino)-1,7-heptanedioic acid

(2RS)-α-Ethyl ω-methyl 2-(N-acetylamino)pimelate

methyl 4-formylbutanoate

Downstream raw materials:

Z-rac-Apm-OH

D-alpha-Aminopimelic acid

7-carboethoxy-tetrahydro-2(3H)-azepinone